CYP11B2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
20 μg | 約20 days | ¥ 65,500 |
100 μg | 約20 days | ¥ 123,500 |
1 mg | 約20 days | ¥ 528,000 |
説明 | CYP11B2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. |
Species | Human |
Expression Host | E. coli |
Tag | N-6xHis-SUMO |
Accession Number | P19099 |
別名 | ALDOS, Corticosterone 18-monooxygenase, CYP11B2, Aldosterone synthase, CYPXIB2, Cytochrome P-450Aldo, Aldosterone-synthesizing enzyme, CYP11B2, Cytochrome P450 11B2, mitochondrial |
Amino Acid | GTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN |
Construction | 25-503 |
Protein Purity | > 90% as determined by SDS-PAGE. |
分子量 | 71.0 kDa (predicted) |
Formulation | Tris-based buffer, 50% glycerol |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone. Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). |
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Please read the User Guide of Recombinant Proteins for more specific information.
CYP11B2 Protein, Human, Recombinant (His & SUMO) ALDOS Corticosterone 18-monooxygenase, CYP11B2 Aldosterone synthase CYPXIB2 Cytochrome P-450Aldo Aldosterone-synthesizing enzyme CYP11B2 Cytochrome P450 11B2, mitochondrial recombinant recombinant-proteins proteins protein