DC-SIGN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.8 kDa and the accession number is Q9NNX6-1.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
100 μg | 在庫あり | ¥ 72,500 |
200 μg | 約5 days | ¥ 128,500 |
500 μg | 約5 days | ¥ 271,000 |
生物学的情報 | Testing in progress |
説明 | DC-SIGN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.8 kDa and the accession number is Q9NNX6-1. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | N-hFc |
Accession Number | Q9NNX6-1 |
別名 | DC-SIGN, CD209 molecule, CDSIGN, CLEC4L, CD209, MGC129965, DC-SIGN1 |
Construction | The N-terminally truncated extracellular domain (Lys 62-Ala 404) of Human DC-SIGN (NP_066978.1) was expressed with the fused Fc region of Human IgG1 at the N-terminus. |
Protein Purity |
> 97 % as determined by SDS-PAGE
|
分子量 | 65.8 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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Please read the User Guide of Recombinant Proteins for more specific information.
DC-SIGN Protein, Human, Recombinant (hFc) CD 209 DC-SIGN CD209 molecule CDSIGN CLEC4L CD209 MGC129965 CD-209 DC-SIGN1 MGC 129965 MGC-129965 recombinant recombinant-proteins proteins protein