DKK3 Protein, Human, Recombinant

DKK3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.29 kDa and the accession number is Q9UBP4.

DKK3 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 138,000
1 mg	約5 days	￥ 897,500

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説明	DKK3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.29 kDa and the accession number is Q9UBP4.

Species	Human
Expression Host	HEK293
Tag	Tag Free
Accession Number	Q9UBP4
別名	REIC, dickkopf WNT signaling pathway inhibitor 3, RIG
Construction	A DNA sequence encoding the human DKK3 (Q9UBP4) (Met1-Ile350) was expressed.
Protein Purity	> 90 % as determined by SDS-PAGE. >90% as determined by SEC-HPLC.
分子量	36.29 kDa (predicted)

Endotoxin	< 1.0 EU per μg protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway.

参考文献

1. Yue W,et al., 2008. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis, 29 (1): 84-92. 2. Ding Z,et al., 2009. Promoter methylation and mRNA expression of DKK3 and WIF-1 in hepatocellular carcinoma. World J Gastroenterol, 15 (21):2595-601.

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DKK3 Protein, Human, Recombinant

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