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FDPS Protein, Human, Recombinant (His)

カタログ番号 TMPY-02654
別名: FPS, FPPS, Farnesyl pyrophosphate synthase

FDPS Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 42.4 kDa and the accession number is P14324-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
FDPS Protein, Human, Recombinant (His)
パッケージサイズ 在庫状況 単価(税別)
50 μg 約5 days ¥ 138,000
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
説明 FDPS Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 42.4 kDa and the accession number is P14324-2.
Species Human
Expression Host E. coli
Tag His
Accession Number P14324-2
別名 FPS, FPPS, Farnesyl pyrophosphate synthase
Construction The Human FDPS isoform b (NP_001129294.1) (Met 1-Lys 353) was expressed, with a polyhistide tag at the N-terminus.
Protein Purity > 85 % as determined by SDS-PAGE
分子量 42.4 kDa (predicted)
Endotoxin Please contact us for more information.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Z-farnesyl diphosphate synthase (FDPS) is an enzyme belonging to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. Z-farnesyl diphosphate synthase (FDPS) functions as key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate, a precurcor for several classes of essential metabolites. FDPS catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Functions of FDPS may be inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.

参考文献

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Keywords

FDPS Protein, Human, Recombinant (His) FPS FPPS Farnesyl pyrophosphate synthase recombinant recombinant-proteins proteins protein