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FGF-10 Protein, Human, Recombinant

カタログ番号 TMPY-01061
別名: fibroblast growth factor 10, KGF2

Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. FGF10 is required for normal branching morphogenesis. It may play a role in wound healing. Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG). ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
FGF-10 Protein, Human, Recombinant
パッケージサイズ 在庫状況 単価(税別)
20 μg 在庫あり ￥ 31,500
100 μg 約5 days ￥ 79,500
200 μg 約5 days ￥ 141,000
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
生物学的情報 1. Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human FGFR2b. The ED50 for this effect is typically 3-30 ng/mL.
2. Human lung cancer organoids were cultured with FGF2 (Cat#TMPY-00749), FGF4 (Cat#TMPY-05004), FGF7 (Cat#TMPY-00403), EGF (Cat#TMPY-03701), FGF10 (Cat#TMPY-01061), NOG (Cat#TMPY-02594), RSPO1 (Cat#TMPY-03626).
3. Human lung organoids were cultured with FGF2 (Cat#TMPY-00749), FGF4 (Cat#TMPY-05004), FGF7 (Cat#TMPY-00403), EGF (Cat#TMPY-03701), FGF10 (Cat#TMPY-01061), NOG (Cat#TMPY-02594), RSPO1 (Cat#TMPY-03626).
4. Human cholangiocarcinomas organoids were cultured with FGF2 (Cat#TMPY-00749), HGF (Cat#TMPY-02327), FGF7 (Cat#TMPY-00403), EGF (Cat#TMPY-03701), FGF10 (Cat#TMPY-01061), NOG (Cat#TMPY-02594), RSPO1 (Cat#TMPY-03626).
5. Human liver cancer organoids were cultured with FGF2 (Cat#TMPY-00749), HGF (Cat#TMPY-02327), FGF7 (Cat#TMPY-00403), EGF (Cat#TMPY-03701), FGF10 (Cat#TMPY-01061), TGFB1 (Cat#TMPY-02638), NOG (Cat#TMPY-02594), RSPO1 (Cat#TMPY-03626).
6. Human kidney cancer organoids were cultured with FGF2 (Cat#TMPY-00749), FGF7 (Cat#TMPY-00403), EGF (Cat#TMPY-03701), FGF10 (Cat#TMPY-01061), NOG (Cat#TMPY-02594), RSPO1 (Cat#TMPY-03626).
7. Human kidney organoids were cultured with FGF7 (Cat#TMPY-00403), EGF (Cat#TMPY-03701), FGF10 (Cat#TMPY-01061), NOG (Cat#TMPY-02594), RSPO1 (Cat#TMPY-03626), HGF (Cat#TMPY-02327), FGF4 (Cat#TMPY-05004).
8. Human gastric cancer organoids were cultured with EGF (Cat#TMPY-03701), FGF10 (Cat#TMPY-01061), NOG (Cat#TMPY-02594), RSPO1 (Cat#TMPY-03626).
9. Human stomach organoids organoids were cultured with EGF (Cat#TMPY-03701), FGF10 (Cat#TMPY-01061), NOG (Cat#TMPY-02594), RSPO1 (Cat#TMPY-03626).
10. Human small intestinal organoids were cultured with IL22 (Cat#TMPY-03490), FGF10 (Cat#TMPY-01061), EGF (Cat#TMPY-03701), NOG (Cat#TMPY-02594).

説明 Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. FGF10 is required for normal branching morphogenesis. It may play a role in wound healing. Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG). ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
Species Human
Expression Host E. coli
Tag Tag Free
Accession Number A0A7U3JW18
別名 fibroblast growth factor 10, KGF2
Construction mature form of Human FGF10 (NP_004456.1) (Gln38-Ser208)
Protein Purity ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

分子量 19.46 kDa (predicted)
Endotoxin < 5 EU/mg of the protein.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping

In general, Lyophilized powders are shipping with blue ice.
Research Background Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. FGF10 is required for normal branching morphogenesis. It may play a role in wound healing. Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG). ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.

参考文献

1. Sekine K,et al.(1999) Fgf10 is essential for limb and lung formation. Nat Genet. 21(1): 138-41. 2. Ohuchi H,et al.(2000) FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem Biophys Res Commun. 277(3): 643-9. 3. Bellusci S,et al.(1997) Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development. 124(23): 4867-78.

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Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

FGF-10 Protein, Human, Recombinant KGF-2 KGF 2 fibroblast growth factor 10 KGF2 recombinant recombinant-proteins proteins protein

 

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