FGF-21 Protein, Hamster, Recombinant (His)

FGF-21 Protein, Hamster, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.16 kDa and the accession number is A0A1U7RD97.

FGF-21 Protein, Hamster, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 124,000

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説明	FGF-21 Protein, Hamster, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.16 kDa and the accession number is A0A1U7RD97.

Species	Hamster
Expression Host	HEK293 Cells
Tag	C-His
Accession Number	A0A1U7RD97
別名	fibroblast growth factor 21
Construction	The hamster FGF21 (XP_005084765.1) (Met1-Ser209)
Protein Purity	> 95 % as determined by SDS-PAGE.
分子量	21.16 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

参考文献

1. Zhang X,et al.(2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53. 2. Lundåsen T,et al.(2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40. 3. Kharitonenkov A,et al.(2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.

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FGF-21 Protein, Hamster, Recombinant (His)

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