FGF-21 Protein, Human, Recombinant

FGF-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.55 kDa and the accession number is NP_061986.1.

FGF-21 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
50 μg	在庫あり	￥ 56,500
100 μg	約5 days	￥ 100,000
200 μg	約5 days	￥ 177,000
500 μg	約5 days	￥ 374,000

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生物学的情報	Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.1-0.6 µg/mL in the presence of Recombinant Mouse Klotho beta.
説明	FGF-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.55 kDa and the accession number is NP_061986.1.

Species	Human
Expression Host	E. coli
Tag	Tag Free
Accession Number	NP_061986.1
別名	UNQ3115 / PRO10196, fibroblast growth factor 21
Construction	A DNA sequence encoding the Human FGF21 (NP_061986.1) (His29-Ser209) was expressed.
Protein Purity	≥ 95 % as determined by SDS-PAGE.
分子量	19.55 kDa (predicted)

Endotoxin	< 10 EU per mg of the protein.
Formulation	Lyophilized from sterile PBS. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

参考文献

1. Zhang X,et al.(2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53. 2. Lundåsen T,et al.(2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40. 3. Kharitonenkov A,et al.(2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.

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FGF-21 Protein, Human, Recombinant

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