FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 12,500 |
50 μg | 約5 days | ¥ 30,000 |
500 μg | 約5 days | ¥ 319,000 |
1 mg | 約5 days | ¥ 454,500 |
説明 | FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
Species | Human |
Expression Host | E. coli |
Tag | C-6xHis |
Accession Number | Q02790 |
別名 | FKBP4, HSP-binding immunophilin, immunophilin FKBP52, FK506-binding protein 4, FKBP59, Rotamase, 59kDa immunophilin, 51kDa FK506-binding protein, Peptidyl-prolyl cis-trans isomerase FKBP4 |
Amino Acid | Met1-Ala459 |
Construction | Met1-Ala459 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 50-60 KDa (reducing condition) |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 10% Glycerol, pH 8.0. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
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Please read the User Guide of Recombinant Proteins for more specific information.
FKBP4 Protein, Human, Recombinant (His) FKBP-59 FKBP4 HSP-binding immunophilin immunophilin FKBP52 FKBP 59 FK506-binding protein 4 FKBP-4 FKBP59 Rotamase FKBP 4 59kDa immunophilin 51kDa FK506-binding protein Peptidyl-prolyl cis-trans isomerase FKBP4 recombinant recombinant-proteins proteins protein