FOLR2 Protein, Human, Recombinant (His)

カタログ番号 TMPY-01280

別名: FBP, β-HFR, FR-P3, BETA-HFR, folate receptor 2 (fetal), FR-BETA, FR-β, FBP/PL-1

Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

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FOLR2 Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	在庫あり	￥ 88,500
200 μg	約5 days	￥ 156,500
500 μg	約5 days	￥ 330,500

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生物学的特性に関する説明

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Product Properties

参考文献

生物学的情報

Testing in progress

説明

Species	Human
Expression Host	HEK293 Cells
Tag	His
Accession Number	P14207-1
別名	FBP, β-HFR, FR-P3, BETA-HFR, folate receptor 2 (fetal), FR-BETA, FR-β, FBP/PL-1
Construction	The Human FOLR2 (P14207-1) without the propeptide (Met 1-His 228) was fused with a polyhistidine tag at the C-terminus.
Protein Purity	> 87 % as determined by SDS-PAGE
分子量	26 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

参考文献

1. van Heyningen V, et al., 1995, Cytogenet Cell Genet. 69 (3-4): 127-58. 2. Sabharanjak, S. et al., 2004, Adv Drug Deliv Rev. 56 (8): 1099-109. 3. Scapoli, L. et al., 2005, Am J Med Genet A. 132A (3): 302-4. 4. Puig-Kröger, A. et al., 2009, Cancer Res 69 (24): 9395-403.

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Keywords

FOLR2 Protein, Human, Recombinant (His) FBP β-HFR FR-P3 folate receptor 2 b-HFR BETA-HFR folate receptor 2 (fetal) FR-BETA FR-β FBP/PL-1 fetal recombinant recombinant-proteins proteins protein