GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
100 μg | 在庫あり | ¥ 79,500 |
200 μg | 約5 days | ¥ 134,500 |
500 μg | 約5 days | ¥ 266,500 |
生物学的情報 | Testing in progress |
説明 | GDF-15 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 13.7 kDa and the accession number is Q99988. |
Species | Human |
Expression Host | P. pastoris (Yeast) |
Tag | N-His |
Accession Number | Q99988 |
別名 | PLAB, PTGFB, NAG-1, MIC1, GDF-15, PDF, MIC-1, growth differentiation factor 15 |
Construction | mature form of Human GDF15 (NP_004855.2) (Ala197-Ile308) |
Protein Purity |
> 90 % as determined by SDS-PAGE.
|
分子量 | 13.7 kDa (predicted) |
Endotoxin | Please contact us for more information. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM HAc, pH 2. 9. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
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Please read the User Guide of Recombinant Proteins for more specific information.
GDF-15 Protein, Human, Recombinant (His) NAG1 PLAB PTGFB GDF15 NAG-1 GDF 15 MIC1 GDF-15 MIC 1 PDF MIC-1 NAG 1 growth differentiation factor 15 recombinant recombinant-proteins proteins protein