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GFR Alpha-1/GFRA1 Protein, Mouse, Recombinant (His)

カタログ番号 TMPY-01088
別名: AU042498, GFR α-1/GFRA1, GDNF family receptor alpha 1, GDNF family receptor α1

GFR Alpha-1/GFRA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.3 kDa and the accession number is P97785-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
GFR Alpha-1/GFRA1 Protein, Mouse, Recombinant (His)
パッケージサイズ 在庫状況 単価(税別)
100 μg 約5 days ¥ 161,000
1 mg 約5 days ¥ 1,049,000
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
説明 GFR Alpha-1/GFRA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.3 kDa and the accession number is P97785-2.
Species Mouse
Expression Host HEK293 Cells
Tag C-His
Accession Number P97785-2
別名 AU042498, GFR α-1/GFRA1, GDNF family receptor alpha 1, GDNF family receptor α1
Construction extracellular domain (Met 1-Ser 425) of Mouse GFRα1 isoform beta (AAB86600.1)
Protein Purity > 98 % as determined by SDS-PAGE
分子量 46.3 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 1 (GFRA1) is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA1 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. GDNF, a distantly related member of the transforming growth factor-β (TGF-â) superfamily, and its receptor components: GFRA1, Ret and neural cell adhesion molecule (NCAM) have been recently reported to be expressed in the testis and to be involved in the proliferation regulation of immature Sertoli cells.

参考文献

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Keywords

GFR Alpha-1/GFRA1 Protein, Mouse, Recombinant (His) AU042498 GFR α-1/GFRA1 GDNF family receptor alpha 1 AU 042498 GDNF family receptor α 1 AU-042498 GDNF family receptor α1 GDNF family receptor a 1 recombinant recombinant-proteins proteins protein