HER2/ERBB2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1.
説明 | HER2/ERBB2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.1 kDa and the accession number is P04626-1. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-hFc |
Accession Number | P04626-1 |
別名 | NEU, CD340, HER-2/neu, HERV7Q, TKR1, erb-b2 receptor tyrosine kinase 2, MLN19, MLN 19, ERVWE1, ENV, HERVW, HERV-7q, HER-2, HERVWENV, EGFR2, NGL, HER2, ENVW, HERV-W-ENV |
Construction | The extracellular domain (Met 1-Thr 652) of Human ErbB2 (NP_004439.2) was fused with the Fc region of Human IgG1 at the C-terminus. |
Protein Purity | ≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. |
分子量 | 96.1 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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Please read the User Guide of Recombinant Proteins for more specific information.
HER2/ERBB2 Protein, Human, Recombinant (hFc) NEU CD340 HER-2/neu HERV7Q TKR1 CD-340 TKR 1 erb-b2 receptor tyrosine kinase 2 MLN19 MLN-19 MLN 19 ERVWE1 ENV CD 340 HERVW HERV-7q TKR-1 HER-2 HERVWENV HER 2 EGFR2 ERVWE 1 NGL HER2 ENVW ERVWE-1 HERV-W-ENV recombinant recombinant-proteins proteins protein