Histone H1 Protein, Human, Recombinant (His)

カタログ番号 TMPY-02580

別名: HSP60, HSP65, CPN60, H1 histone family, member 0, H10, HLD4, HSPD1, HuCHA60, H1FV, SPG13, GROEL

H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "beads on a string" sub-structure into a high order structure. The lysine-rich H1 histone family in mammals includes eleven members. In higher eukaryotes, all H1 variants have the same general structure, consisting of a central conserved globular domain and less conserved N-terminal and C-terminal tails. These tails are moderately conserved among species, but differ among variants, suggesting a specific function for each H1 variant. Studies on the role of particular subtypes at specific developmental stages in lower eukaryotes, but also in vertebrates suggest that specific subtypes of H1 participate in particular systems of gene regulation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Histone H1 Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	在庫あり	￥ 103,500
200 μg	約5 days	￥ 177,000
500 μg	約5 days	￥ 358,000

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生物学的特性に関する説明

Technical Params

Product Properties

参考文献

生物学的情報

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説明

Species	Human
Expression Host	E. coli
Tag	His
Accession Number	P07305
別名	HSP60, HSP65, CPN60, H1 histone family, member 0, H10, HLD4, HSPD1, HuCHA60, H1FV, SPG13, GROEL
Construction	The Human H1F0 (P07305) (Met 1-Lys 194) was expressed, with a polyhistide tag at the N-terminus.
Protein Purity	≥ 92 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	22.4 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 600 mM NaCl, 1 mM DTT, pH 8.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "beads on a string" sub-structure into a high order structure. The lysine-rich H1 histone family in mammals includes eleven members. In higher eukaryotes, all H1 variants have the same general structure, consisting of a central conserved globular domain and less conserved N-terminal and C-terminal tails. These tails are moderately conserved among species, but differ among variants, suggesting a specific function for each H1 variant. Studies on the role of particular subtypes at specific developmental stages in lower eukaryotes, but also in vertebrates suggest that specific subtypes of H1 participate in particular systems of gene regulation.

参考文献

1. Ramakrishnan V,et al. (1993) Crystal structure of globular domain of histone H5 and its implications for nucleosome binding. Nature. 362 (6417): 219-23. 2. Happel N,et al. (2009) Histone H1 and its isoforms: contribution to chromatin structure and function. Gene. 431 (1-2): 1-12. 3. Izzo A,et al. (2008) The histone H1 family: specific members, specific functions. Biol Chem. 389 (4): 333-43.

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Keywords

Histone H1 Protein, Human, Recombinant (His) SPG-13 HSP60 HSP65 CPN-60 CPN60 HLD-4 HSP 60 H1 histone family, member 0 H10 H-10 HLD4 H 10 CPN 60 HSP 65 SPG 13 HLD 4 HSPD 1 HSPD1 HSPD-1 HuCHA60 HSP-65 H1FV SPG13 HSP-60 GROEL recombinant recombinant-proteins proteins protein