I-309 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35 kDa and the accession number is P22362.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
100 μg | 在庫あり | ¥ 79,500 |
200 μg | 約5 days | ¥ 136,000 |
500 μg | 約5 days | ¥ 275,500 |
生物学的情報 | Testing in progress |
説明 | I-309 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35 kDa and the accession number is P22362. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | hFc |
Accession Number | P22362 |
別名 | chemokine (C-C motif) ligand 1, TCA3, SISe, I-309, SCYA1, P500 |
Construction | The mature form of Human CCL1 (NP_002972.1) (Lys 24-Lys 96) was fused with the Fc region of Human IgG1 at the N-terminus. |
Protein Purity |
> 90 % as determined by SDS-PAGE
|
分子量 | 35 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that I-309/CCL1/TCA-3 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, I-309/CCL1/TCA-3 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. I-309/CCL1/TCA-3 induces significant levels of LTC4 from elicited eosinophils. |
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Please read the User Guide of Recombinant Proteins for more specific information.
I-309 Protein, Human, Recombinant (hFc) chemokine (C-C motif) ligand 1 I309 TCA3 SCYA-1 I 309 SCYA 1 SISe I-309 SCYA1 TCA-3 P-500 P500 TCA 3 P 500 recombinant recombinant-proteins proteins protein