IFN-beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.7 kDa and the accession number is A0A7R8GV38.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
100 μg | 在庫あり | ¥ 91,500 |
200 μg | 約5 days | ¥ 156,000 |
500 μg | 約5 days | ¥ 314,500 |
生物学的情報 |
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The ED50 for this effect is 0.08-0.8 ng/mL.
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説明 | IFN-beta Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.7 kDa and the accession number is A0A7R8GV38. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | hFc |
Accession Number | A0A7R8GV38 |
別名 | IFNB, IFN-β, Interferon beta, interferon, beta 1, fibroblast, Interferon β, IFN-beta, IFB, interferon, β1, fibroblast, IFF |
Construction | The Human IFNβ (NP_002167.1) (Met 1-Asn 187) was fused with the Fc region of Human IgG1 at the C-terminus. |
Protein Purity |
> 95 % as determined by SDS-PAGE
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分子量 | 46.7 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites, and tumor cells. Interferon-beta (IFN beta) is an extracellular protein mediator of host defense and homeostasis. IFN beta has well-established direct antiviral, antiproliferative, and immunomodulatory properties. Recombinant IFN beta is approved for the treatment of relapsing-remitting multiple sclerosis. The recombinant IFN beta protein has the theoretical potential to either treat or causes autoimmune neuromuscular disorders by altering the complicated and delicate balances within the immune system networks. It is the most widely prescribed disease-modifying therapy for multiple sclerosis (MS). Large-scale clinical trials have established the clinical efficacy of IFN beta in reducing relapses and slowing disease progression in relapsing-remitting MS. IFN beta therapy was shown to be comparably beneficial for opticospinal MS (OSMS) and conventional MS in Japanese. IFN beta is effective in reducing relapses in secondary progressive MS and may have a modest effect in slowing disability progression. In addition to the common antiviral activity, IFN beta also induces increased production of the p53 gene product which promotes apoptosis and thus has a therapeutic effect against certain cancers. The role of IFN-beta in bone metabolism could warrant its systematic evaluation as a potential adjunct to therapeutic regimens of osteolytic diseases. Furthermore, IFN beta might play a beneficial role in the development of chronic progressive CNS inflammation.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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Please read the User Guide of Recombinant Proteins for more specific information.
IFN-beta Protein, Human, Recombinant (hFc) IFNB IFN-β Interferon beta interferon, beta 1, fibroblast Interferon β IFN-beta interferon, β 1, fibroblast IFB interferon, β1, fibroblast IFF interferon, b 1, fibroblast recombinant recombinant-proteins proteins protein