Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 30,000 |
50 μg | 約5 days | ¥ 89,500 |
500 μg | 約5 days | ¥ 436,000 |
1 mg | 約5 days | ¥ 626,500 |
説明 | Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. |
Species | Rhesus |
Expression Host | HEK293 Cells |
Tag | C-6xHis |
Accession Number | A0A7N9D7J0 |
別名 | IFN-al, CRF2-1, IFN-alpha/beta receptor 1, human interferon-α receptor (HuIFN-α-Rec)10IFRC, α-type antiviral protein, AVP, Cytokine receptor family 2 member 1, IFN-alpha/beta R1, beta-type antiviral protein, IFN-α/β receptor 1, IFN-α/β R1, Cytokine receptor class-II member 1, β-type antiviral protein, human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC, alpha-type antiviral protein |
Amino Acid | Ala25-Lys437 |
Construction | Ala25-Lys437 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 70-120 KDa, reducing conditions |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. |
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Please read the User Guide of Recombinant Proteins for more specific information.
IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al CRF2-1 b-type antiviral protein IFN-a/b R1 human interferon-a receptor (HuIFN-a-Rec)10IFRC IFN-alpha/beta receptor 1 human interferon-α receptor (HuIFN-α-Rec)10IFRC α-type antiviral protein AVP Cytokine receptor family 2 member 1 IFN-alpha/beta R1 beta-type antiviral protein IFN-α/β receptor 1 IFN-α/β R1 Cytokine receptor class-II member 1 IFN-a/b receptor 1 a-type antiviral protein β-type antiviral protein human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC alpha-type antiviral protein recombinant recombinant-proteins proteins protein