IgG1 hFc Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32 KDa and the accession number is P01857.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 8,000 |
50 μg | 約5 days | ¥ 25,500 |
500 μg | 約5 days | ¥ 129,500 |
1 mg | 約5 days | ¥ 185,000 |
説明 | IgG1 hFc Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32 KDa and the accession number is P01857. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | Tag Free |
Accession Number | P01857 |
別名 | IGHG1, g gamma-1 chain C region, g γ-1 chain C region |
Amino Acid | Asp104-Lys330(Asp239Glu,Leu241Met) |
Construction | Asp104-Lys330(Asp239Glu,Leu241Met) |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 32 KDa (reducing condition) |
Endotoxin | < 1 EU/μg by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. |
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Please read the User Guide of Recombinant Proteins for more specific information.
IgG1 hFc Protein, Human, Recombinant IGHG1 IGHG-1 g gamma-1 chain C region g γ-1 chain C region IGHG 1 recombinant recombinant-proteins proteins protein