IL-11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.1 kDa and the accession number is AAH12506.1.
| 生物学的情報 |
1.Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 1-8 ng/mL.
2.Loaded Human IL11RA Protein, His Tag on His1K Biosensor, can bind Human IL11 protein with an affinity constant of 0.353nM as determined in BLI assay (Routinely tested).
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| 説明 |
IL-11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.1 kDa and the accession number is AAH12506.1. |
| Species |
Human
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| Expression Host |
E. coli
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| Tag |
Tag Free
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| Accession Number |
AAH12506.1
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| 別名 |
interleukin 11, IL-11, AGIF
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| Construction |
A DNA sequence encoding the mature form of human IL11 (AAH12506.1) (Pro22-Leu199) was expressed.
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| Protein Purity |
> 90 % as determined by SDS-PAGE
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| 分子量 |
19.1 kDa (predicted)
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| Endotoxin |
Please contact us for more information.
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| Formulation |
Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
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| Reconstitution |
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
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| Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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| Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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| Research Background |
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.
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参考文献
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Recombinant Proteins Dilute Calculator
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