IL-17A Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q16552.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
100 μg | 約5 days | ¥ 105,500 |
200 μg | 約5 days | ¥ 187,500 |
500 μg | 約5 days | ¥ 397,000 |
説明 | IL-17A Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q16552. |
Species | Human |
Expression Host | P. pastoris (Yeast) |
Tag | N-His |
Accession Number | Q16552 |
別名 | CTLA-8, CTLA8, interleukin 17A, IL17, IL-17A, IL-17 |
Construction | Human IL17A (Q16552, with mutation Thr 26 Ala) (Gly24-Ala155) |
Protein Purity | > 90 % as determined by SDS-PAGE |
分子量 | 17.3 kDa (predicted) |
Endotoxin | Please contact us for more information. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
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Please read the User Guide of Recombinant Proteins for more specific information.
IL-17A Protein, Human, Recombinant (His) IL 17 CTLA-8 CTLA8 CTLA 8 interleukin 17A IL17 IL-17A IL-17 recombinant recombinant-proteins proteins protein