IL-1F8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.3 kDa and the accession number is Q9NZH7-2.
説明 | IL-1F8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.3 kDa and the accession number is Q9NZH7-2. |
Species | Human |
Expression Host | E. coli |
Tag | N-His |
Accession Number | Q9NZH7-2 |
別名 | FIL1, FIL1H, IL1-ETA, interleukin 36, β, FIL1-(ETA), IL1H2, interleukin 36, beta, IL1F8, IL36B, IL-1F8, FILI-(ETA), IL-1H2 |
Construction | mature form of Human IL1F8 (NP_775270.1) (Lys 5-Glu 157) |
Protein Purity | > 95 % as determined by SDS-PAGE |
分子量 | 19.3 kDa (predicted) |
Endotoxin | Please contact us for more information. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includes four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB. |
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Please read the User Guide of Recombinant Proteins for more specific information.
IL-1F8 Protein, Human, Recombinant (His) FIL 1 FIL1 FIL1H IL1-ETA interleukin 36, β FIL1-(ETA) IL1H2 interleukin 36, beta IL1F8 IL36B IL-1F8 FIL-1 FILI-(ETA) IL-1H2 recombinant recombinant-proteins proteins protein