IL-22 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.9 kDa and the accession number is A0A7R8C389.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
20 μg | 在庫あり | ¥ 41,000 |
100 μg | 約5 days | ¥ 102,500 |
200 μg | 約5 days | ¥ 181,500 |
500 μg | 約5 days | ¥ 597,000 |
生物学的情報 |
Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is typically 0.3-1.2 ng/mL.
|
説明 | IL-22 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.9 kDa and the accession number is A0A7R8C389. |
Species | Human |
Expression Host | E. coli |
Tag | Tag Free |
Accession Number | A0A7R8C389 |
別名 | IL-TIF, IL-22, interleukin 22, IL-D110, TIFa, TIFIL-23, ILTIF, zcyto18 |
Construction | Human IL22(NP_065386.1) (Ala34-Ile179) was expressed with a N-terminal Met. |
Protein Purity |
> 95 % as determined by SDS-PAGE
|
分子量 | 16.9 kDa (predicted) |
Endotoxin | Please contact us for more information. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | IL22 is a member of a group of cytokines called the IL-1 family of IL-1 superfamily (including IL-19, IL-2, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares the use of IL-1R2 in cell signaling with other members of this family, IL-1, IL-26, IL-28A/B, and IL-29. IL22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. IL22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-1R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (SIL-22R1). IL22 and IL-1 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL22 can contribute to immune disease through the stimulation of inflammatory responses, S1s, and defensins. IL22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-1. In some contexts, the pro-inflammatory versus tissue-protective functions of IL22 are regulated by the often co-expressed cytokine IL-17A. |
bottom
Please read the User Guide of Recombinant Proteins for more specific information.
IL-22 Protein, Human, Recombinant IL-TIF TIFIL23 TIFIL 23 IL22 IL 22 IL-22 IL-D-110 interleukin 22 IL-D110 TIFa TIFIL-23 ILTIF IL-D 110 zcyto18 recombinant recombinant-proteins proteins protein