IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant

IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P48090.

IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant

パッケージサイズ	在庫状況	単価(税別)
20 μg	在庫あり	￥ 41,000
100 μg	約5 days	￥ 114,500
200 μg	約5 days	￥ 201,000
500 μg	約5 days	￥ 422,500

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生物学的情報	Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.25-1 ng/mL.
説明	IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P48090.

Species	Rhesus
Expression Host	E. coli
Tag	Tag Free
Accession Number	P48090
別名	interleukin 1, beta, IL-1 β, interleukin 1, β
Construction	The mature form of rhesus IL1B (NP_001036221.1) (Ala117-Ser269) was expressed and purified, with an initial Met.
Protein Purity	> 97 % as determined by SDS-PAGE
分子量	17.5 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, pH 8.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Kim SH,et al.(2008) Association of -31TC and -511 CT polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 14:2109-16. 2. Wang ZC,et al.(2002) T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes Immun. 3(1): 38-42. 3. Mattuzzi S,et al.(2007) Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis. J Rheumatol. 34(5): 997-1004.

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IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant

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