IL-22BP Protein, Human, Recombinant (hFc)

IL-22BP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55 kDa and the accession number is Q969J5-1.

IL-22BP Protein, Human, Recombinant (hFc)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 161,000

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説明	IL-22BP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55 kDa and the accession number is Q969J5-1.

Species	Human
Expression Host	HEK293 Cells
Tag	C-hFc
Accession Number	Q969J5-1
別名	IL-22BP, CRF2X, ZCYTOR16, IL-22R-α-2, interleukin 22 receptor, α2, CRF2-S1, IL-22RA2, interleukin 22 receptor, alpha 2, CRF2-10, IL-22R-alpha-2
Construction	The Human IL22RA2 (NP_443194.1) (Met1-Pro263) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity	> 90 % as determined by SDS-PAGE.
分子量	55 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type II cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in the placenta, spleen, breast, skin, and lung. It is also detected in the intestinal tract, testis, brain, heart, and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of the IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important role in the immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptors have been discovered, a membrane-bound receptor and a soluble receptor.

参考文献

1. Whittington HA,et al.(2004) Interleukin-22: a potential immunomodulatory molecule in the lung. Am J Respir Cell Mol Biol. 31(2): 220-6. 2. Dumoutier L,et al.(2001) Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol. 166(12): 7090-5. 3. Wei CC,et al.(2003) Cloning and characterization of mouse IL-22 binding protein. Genes Immun. 4(3): 204-11.

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IL-22BP Protein, Human, Recombinant (hFc)

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