IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
20 μg | 在庫あり | ¥ 36,000 |
100 μg | 約5 days | ¥ 91,500 |
200 μg | 約5 days | ¥ 161,000 |
500 μg | 約5 days | ¥ 530,500 |
生物学的情報 |
Measured in a cell proliferation assay using T1165 mouse plasmacytoma cells. The ED50 for this effect is typically 0.1-0.8 ng/mL.
|
説明 | IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505. |
Species | Mouse |
Expression Host | E. coli |
Tag | Tag Free |
Accession Number | P08505 |
別名 | Il-6, interleukin 6 |
Construction | A DNA sequence encoding the mouse IL6 (P08505) (Phe25-Thr211) was expressed and purified. |
Protein Purity |
> 90 % as determined by SDS-PAGE
|
分子量 | 21.9 kDa (predicted) |
Endotoxin | < 1.0 EU per μg protein as determined by the LAL method. |
Formulation | Lyophilized from sterile 50mM HAc, pH3. 0Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
bottom
Please read the User Guide of Recombinant Proteins for more specific information.
IL-6 Protein, Mouse, Recombinant Il-6 interleukin 6 recombinant recombinant-proteins proteins protein