IL-7 Protein, Human, Recombinant

IL-7 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P13232-1.

IL-7 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
10 μg	在庫あり	￥ 29,000
20 μg	約5 days	￥ 44,000
50 μg	約5 days	￥ 75,500
100 μg	約5 days	￥ 114,500
200 μg	約5 days	￥ 195,500
500 μg	約5 days	￥ 397,000

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生物学的情報	Measured in a cell proliferation assay using anti-CD3 antibody activated human peripheral blood mononuclear cell (PBMC). The ED50 for this effect is typically 0.5-8 ng/ml.
説明	IL-7 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P13232-1.

Species	Human
Expression Host	E. coli
Tag	Tag Free
Accession Number	P13232-1
別名	IL-7, interleukin 7, Interleukin-7
Construction	The mature form of Human IL7 (NP_000871.1)(Asp26-His177) was expressed with a N-terminal Met.
Protein Purity	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	17.5 kDa (predicted)

Endotoxin	< 0.01 EU/μg of the protein.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	IL7, also known as interleukin 7, is a hematopoietic growth factor that belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells and may serve as a regulatory factor for intestinal mucosal lymphocytes.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Watanabe M,et al.(1995) Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.J Clin Invest. 95(6):2945-53. 2. Sawa Y,et al.(2009) Hepatic interleukin-7 expression regulates T cell responses. Immunity. 30 (3):447-57. 3. Flad HD,et al.(1996) Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol. 26(10): 2541-4.

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IL-7 Protein, Human, Recombinant

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