IL-7 Protein, Mouse, Recombinant

IL-7 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P10168.

IL-7 Protein, Mouse, Recombinant

パッケージサイズ	在庫状況	単価(税別)
10 μg	在庫あり	￥ 24,500
20 μg	約5 days	￥ 38,000
50 μg	約5 days	￥ 67,000
100 μg	約5 days	￥ 102,500
200 μg	約5 days	￥ 181,000

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生物学的情報	Measured in a cell proliferation assay using antibody against CD3-activated human peripheral blood mononuclear cell (PBMC). The ED50 for this effect is typically 0.4-4 ng/mL.
説明	IL-7 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P10168.

Species	Mouse
Expression Host	E. coli
Tag	Tag Free
Accession Number	P10168
別名	Il-7, A630026I06Rik, interleukin 7, hlb368
Construction	The Mouse IL7 (NP_032397.1) (Glu26-Ile154) was expressed and purified with an initial Met.
Protein Purity	> 90 % as determined by SDS-PAGE
分子量	15 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	IL7, also known as interleukin 7, is a hematopoietic growth factor that belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells and may serve as a regulatory factor for intestinal mucosal lymphocytes.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Watanabe M,et al.(1995) Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.J Clin Invest. 95(6):2945-53. 2. Sawa Y,et al.(2009) Hepatic interleukin-7 expression regulates T cell responses. Immunity. 30 (3):447-57. 3. Flad HD,et al.(1996) Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction. Eur J Immunol. 26(10): 2541-4.

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IL-7 Protein, Mouse, Recombinant

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