Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)

カタログ番号 TMPY-02516

別名: interferon, α10, interferon, alpha 10, IFN-alphaC, MGC119879, MGC119878, Interferon α10/IFNA10, IFN-αC

Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes, and they increase the ability of uninfected host cells to resist new infection by the virus. Certain host symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Human IFNs are divided on the sequence of amino-acids into three groups: Alpha, Beta, and Gamma interferons.

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Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 124,000

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生物学的特性に関する説明

Technical Params

Product Properties

参考文献

説明

Species	Human
Expression Host	HEK293 Cells
Tag	N-hFc
Accession Number	P01566
別名	interferon, α10, interferon, alpha 10, IFN-alphaC, MGC119879, MGC119878, Interferon α10/IFNA10, IFN-αC
Construction	The Human IFNA10 (P01566) (Cys 24-Asp 189) was fused with the Fc region of Human IgG1 at the N-terminus.
Protein Purity	> 85 % as determined by SDS-PAGE
分子量	48 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes, and they increase the ability of uninfected host cells to resist new infection by the virus. Certain host symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Human IFNs are divided on the sequence of amino-acids into three groups: Alpha, Beta, and Gamma interferons.

参考文献

1. De Veer MJ, et al. (2001) Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol. 69 (6): 912-20. 2. Liu YJ. (2005) IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol. 23: 275-306. 3. Fensterl V, et al. (2009) Interferons and viral infections. Biofactors. 35 (1): 14-20.

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Keywords

Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc) MGC-119879 interferon, α 10 MGC 119878 MGC-119878 interferon, a 10 interferon, α10 interferon, alpha 10 IFN-alphaC MGC119879 MGC119878 MGC 119879 Interferon α10/IFNA10 IFN-αC recombinant recombinant-proteins proteins protein