KIR2DL3 Protein, Human, Recombinant (hFc)

KIR2DL3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q32WE4.

KIR2DL3 Protein, Human, Recombinant (hFc)

パッケージサイズ	在庫状況	単価(税別)
100 μg	在庫あり	￥ 88,500
200 μg	約5 days	￥ 151,500
500 μg	約5 days	￥ 307,500

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生物学的情報	Testing in progress
説明	KIR2DL3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q32WE4.

Species	Human
Expression Host	HEK293 Cells
Tag	C-hFc
Accession Number	Q32WE4
別名	KIR-K7b, CU464054.1, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3, NKAT2, p58, CD158b, NKAT2B, NKAT, GL183, KIR2DS5, NKAT2A, MGC129943, KIR-023GB, KIR-K7c, KIRCL23, CD158B2
Construction	The Human KIR2DL3 (AAX23102.1) (Met1-His245) was expressed with the Fc region of Human IgG1 at the C-terminus.
Protein Purity	> 90 % as determined by SDS-PAGE.
分子量	51.6 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Killer cell immunoglobulin-like receptor 2DL3, also known as CD158 antigen-like family member B2, KIR-23GB, Killer inhibitory receptor cl 2-3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated transcript 2, p58 natural killer cell receptor clone CL-6, p58.2 MHC class-I-specific NK receptor, CD158b2, and KIR2DL3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. KIR2DL3 contains 2 Ig-like C2-type (immunoglobulin-like) domains. KIR2DL3 interacts with ARRB2. KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3, and HLA-Cw7). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

参考文献

1. Selvakumar A., et al., 1997, Immunol. Rev. 155:183-196. 2. Wilson M.J., et al., 1997, Tissue Antigens 49:574-579. 3. Maenaka K., et al., 1999, Structure 7:391-398. 4. Vitale,M. et al., 2004, Int Immunol. 16 (10):1459-66. 5. Yu M.-C., et al., 2008, Nat. Immunol. 9:898-907.

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KIR2DL3 Protein, Human, Recombinant (hFc)

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