Kallikrein 5/KLK5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40 KDa and the accession number is Q9Y337.
| 生物学的情報 |
Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is 622 pmol/min/µg, as measured under the described conditions. (Regularly tested)
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| 説明 |
Kallikrein 5/KLK5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40 KDa and the accession number is Q9Y337. |
| Species |
Human
|
| Expression Host |
Human Cells
|
| Tag |
C-6His
|
| Accession Number |
Q9Y337
|
| 別名 |
Stratum Corneum Tryptic Enzyme, Kallikrein-Like Protein 2, KLK5, Kallikrein-5, KLK-L2, SCTE
|
| Amino Acid |
Val23-Ser293
|
| Construction |
Recombinant Human Kallikrein 5 is produced by our Mammalian expression system and the target gene encoding Val23-Ser293 is expressed with a 6His tag at the C-terminus.
|
| Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
|
| 分子量 |
40 KDa, reducing conditions
|
| Endotoxin |
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
|
| Formulation |
Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
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| Stability & Storage |
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
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| Shipping |
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
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| Research Background |
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
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