LAIR2 Protein, Human, Recombinant

LAIR2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.1 kDa and the accession number is Q6ISS4-1.

LAIR2 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 138,000
1 mg	約5 days	￥ 897,500

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説明	LAIR2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.1 kDa and the accession number is Q6ISS4-1.

Species	Human
Expression Host	HEK293 Cells
Tag	Tag Free
Accession Number	Q6ISS4-1
別名	LAIR2, leukocyte associated immunoglobulin like receptor 2, MGC71634, XXbac-BCX535A19.6, CD306
Construction	The Human LAIR2 (NP_002279.2) (Met 1-Pro 152) was expressed and purified.
Protein Purity	> 93 % as determined by SDS-PAGE
分子量	14.1 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 0.7M NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD306, is a 131 amino acid protein containing one Ig-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.

参考文献

1. Meyaard, L. et al.,1997, Immunity.7:283-290. 2. Meyaard, L. et al.,1999, J. Immunol. 162:5800-5804. 3. Meyaard, L. et al., 2001, J. Exp. Med. 194 (1): 107-112. 4. Meyaard, L., 2003, J Biol Regul Homeost Agents. 17 (4): 330-333. 5. Lebbink, R. J. et al., 2008, J Immunol. 180 (3):1662-1669. 6. Lebbink,R.J. et al., 2009, Matrix Biol. 28 (4):202-210.

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LAIR2 Protein, Human, Recombinant

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