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LGMN Protein, Human, Recombinant (His)

カタログ番号 TMPK-01146
別名: AI746452, Legumain, LGMN1, Prsc1, AEP, LGMN, AU022324

Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.

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LGMN Protein, Human, Recombinant (His)
パッケージサイズ 在庫状況 単価(税別)
100 μg 約5 days ¥ 85,500
500 μg 約5 days ¥ 342,000
1 mg 約5 days ¥ 569,500
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
説明 Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.
Species Human
Expression Host HEK293 Cells
Tag N-His
Accession Number Q99538-1
別名 AI746452, Legumain, LGMN1, Prsc1, AEP, LGMN, AU022324
Construction Val18-Tyr433
Protein Purity > 95% as determined by Tris-Bis PAGE
分子量 48.6 kDa (predicted). Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
Endotoxin < 1 EU/μg by the LAL method.
Formulation Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Stability & Storage

It is recommended to store the product under sterile conditions at -70℃ or lower. Samples are stable for up to 12 months at -80℃. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.

参考文献

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Keywords

LGMN Protein, Human, Recombinant (His) LGMN-1 AI746452 AU 022324 AU-022324 LGMN 1 AI 746452 Legumain LGMN1 Prsc1 AEP AI-746452 LGMN AU022324 recombinant recombinant-proteins proteins protein