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LIFR Protein, Human, Recombinant (His)

カタログ番号 TMPY-00991
別名: STWS, CD118, SJS2, LIF-R, leukemia inhibitory factor receptor alpha, SWS, leukemia inhibitory factor receptor α

LIFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 91 kDa and the accession number is P42702-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
LIFR Protein, Human, Recombinant (His)
パッケージサイズ 在庫状況 単価(税別)
100 μg 在庫あり ¥ 88,500
200 μg 約5 days ¥ 156,500
500 μg 約5 days ¥ 330,500
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生物学的特性に関する説明
Technical Params
Product Properties
参考文献
生物学的情報 Immobilized LIF Protein, Human, Recombinant (hFc Tag) at 2 μg/mL (100 μL/well) can bind LIFR Protein, Human, Recombinant (His Tag), the EC50 is 60-360 ng/mL.

説明 LIFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 91 kDa and the accession number is P42702-1.
Species Human
Expression Host HEK293 Cells
Tag His
Accession Number P42702-1
別名 STWS, CD118, SJS2, LIF-R, leukemia inhibitory factor receptor alpha, SWS, leukemia inhibitory factor receptor α
Construction extracellular domain of Human LIFR (NP_001121143.1) (Met 1-Ser 833) with a C-terminal polyhistidine tag
Protein Purity ≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

分子量 91 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.

参考文献

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Keywords

LIFR Protein, Human, Recombinant (His) SJS-2 STWS CD118 CD-118 SJS2 CD 118 SJS 2 LIF-R leukemia inhibitory factor receptor alpha SWS leukemia inhibitory factor receptor α recombinant recombinant-proteins proteins protein