LSAMP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59 kDa and the accession number is Q13449.
| 説明 |
LSAMP Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 59 kDa and the accession number is Q13449. |
| Species |
Human
|
| Expression Host |
HEK293 Cells
|
| Tag |
C-hFc
|
| Accession Number |
Q13449
|
| 別名 |
limbic system-associated membrane protein, FLJ35396, FLJ34254, FLJ37216, LAMP, IGLON3, FLJ54658
|
| Construction |
The Human LSAMP (Q13449) (Met 1-Asn 315), without the pro peptide, was was fused with the Fc region of Human IgG1 at the C-terminus.
|
| Protein Purity |
> 97 % as determined by SDS-PAGE
|
| 分子量 |
59 kDa (predicted)
|
| Endotoxin |
< 1.0 EU/μg of the protein as determined by the LAL method.
|
| Formulation |
Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
|
| Reconstitution |
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
|
| Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
|
| Shipping |
In general, Lyophilized powders are shipping with blue ice.
|
| Research Background |
The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning, and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there has been found that rats with an increased level of anxiety had 1.6-fold higher expression of the LsAMP gene in the periaqueductal gray compared to rats with a low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.
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参考文献
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