MARCO Protein, Mouse, Recombinant (His)

カタログ番号 TMPY-01246

別名: AI323439, Ly112, macrophage receptor with collagenous structure, Scara2

Macrophage receptor MARCO, also known as Macrophage receptor with collagenous structure and Marco, is a single-pass type II membrane protein. MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. It is expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes. Although it is expressed on subsets of macrophages, it can be upregulated on other macrophages after bacterial infection. The strategic position of MARCO-expressing cells in lymphoid organs suggests an important role for this bacteria-binding molecule in the removal of pathogens. MARCO has a short N-terminal cytoplasmic domain, a transmembrane domain, and a large extracellular part composed of a 75-residue long spacer domain, a 27-residue collagenous domain, and a 99-residue long scavenger receptor cysteine-rich (SRCR) domain. It is possible that cooperation between the SRCR domain and the collagenous domain is needed for high-affinity bacterial binding, or that the SRCR domain has to be in a trimeric form to effectively bind to bacteria

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MARCO Protein, Mouse, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 138,000

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Product Properties

参考文献

説明

Species	Mouse
Expression Host	HEK293 Cells
Tag	N-His
Accession Number	A2RT24
別名	AI323439, Ly112, macrophage receptor with collagenous structure, Scara2
Construction	The extracellular domain of Mouse MARCO (NP_034896.1) (Gln 70-Ser 518) was expressed, fused with a polyhistidine tag at the N-terminus.
Protein Purity	> 92 % as determined by SDS-PAGE
分子量	47.3 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Macrophage receptor MARCO, also known as Macrophage receptor with collagenous structure and Marco, is a single-pass type II membrane protein. MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. It is expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes. Although it is expressed on subsets of macrophages, it can be upregulated on other macrophages after bacterial infection. The strategic position of MARCO-expressing cells in lymphoid organs suggests an important role for this bacteria-binding molecule in the removal of pathogens. MARCO has a short N-terminal cytoplasmic domain, a transmembrane domain, and a large extracellular part composed of a 75-residue long spacer domain, a 27-residue collagenous domain, and a 99-residue long scavenger receptor cysteine-rich (SRCR) domain. It is possible that cooperation between the SRCR domain and the collagenous domain is needed for high-affinity bacterial binding, or that the SRCR domain has to be in a trimeric form to effectively bind to bacteria

参考文献

1. Kraal, G. et al., 2000, Microbes Infect . 2 (3): 313-6. 2. Sankala, M., 2002, J Biol Chem. 277 (36): 33378-85. 3. Arredouani, MS., 2004, Cell Mol Biol. 50 Online Pub : OL657-65. 4. Thakur, SA., 2009, Toxicol Sci. 107 (1): 238-46.

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Keywords

MARCO Protein, Mouse, Recombinant (His) AI-323439 AI323439 Ly112 macrophage receptor with collagenous structure Scara2 AI 323439 recombinant recombinant-proteins proteins protein