MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc)

MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q9R007-1.

MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 85,500
500 μg	約5 days	￥ 342,000
1 mg	約5 days	￥ 569,500

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説明	MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q9R007-1.

Species	Mouse
Expression Host	HEK293 Cells
Tag	N-hFc
Accession Number	Q9R007-1
別名	MDL1, DAP12-associating lectin 1, MDL-1, CLEC5A, CLECSF5
Construction	Tyr26-Lys190
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	46.2 kDa (predicted). Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result.

Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	In C. elegans, increased lifespan in daf-2 insulin/IGF-1 receptor mutants is accompanied by up-regulation of the MDL-1 Mad basic helix-loop-helix leucine zipper transcription factor.MDL-1, like its mammalian orthologs, is an inhibitor of cell proliferation and growth that slows progression of an age-related pathology in C. elegans (uterine tumors). In addition, intestine-limited rescue of mdl-1 increased lifespan but not to wild type levels. Thus, mdl-1 likely acts both in the intestine and the germline to influence age-related mortality.

参考文献

1. Riesen M, et al. MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans. Aging (Albany NY). 2014 Feb;6(2):98-117. doi: 10.18632/aging.100638. PMID: 24531613; PMCID: PMC3969279.

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MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc)

参考文献

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