MST3 Protein, Human, Recombinant (His)

Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury.

MST3 Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 114,500

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説明

Species	Human
Expression Host	Baculovirus Insect Cells
Tag	His
Accession Number	Q9Y6E0-2
別名	HEL-S-95, STE20, MST3B, RP11-111L24.5, MST3, STK3, serine/threonine kinase 24
Construction	The Human STK24 isoform A (Q9Y6E0-2) (Met 1-His 431) was expressed, with a polyhistidine tag at the N-terminus.
Protein Purity	> 82 % as determined by SDS-PAGE
分子量	50.3 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 20% gly, 0.1 mM EGTA, 0.1 mM EDTA, 0.25 mM DTT.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
Research Background	Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury.

参考文献

1. Lu TJ,et al.(2006) Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. J Biol Chem. 281(50): 38405-17. 2. Lu TJ,et al.(2005) Zinc ion acts as a cofactor for serine/threonine kinase MST3 and has a distinct role in autophosphorylation of MST3. J Inorg Biochem. 99(6): 1306-13. 3. Schinkmann K,et al.(1997) Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. J Biol Chem. 272 (45): 28695-703.

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MST3 Protein, Human, Recombinant (His)

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