NAALADL1 Protein, Human, Recombinant (His)

NAALADL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80 kDa and the accession number is Q9UQQ1-1.

NAALADL1 Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 138,000

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説明	NAALADL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80 kDa and the accession number is Q9UQQ1-1.

Species	Human
Expression Host	HEK293 Cells
Tag	N-His
Accession Number	Q9UQQ1-1
別名	N-acetylated alpha-linked acidic dipeptidase-like 1, I100, N-acetylated α-linked acidic dipeptidase-like 1, NAALADASEL, NAALADL1
Construction	The extracellular domain of Human NAALADL1 (NP_005459.2) (Pro 29-Leu 740) was expressed, with a polyhistidine tag at the N-terminus.
Protein Purity	> 97 % as determined by SDS-PAGE
分子量	80 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidyl-peptidase, is a Single-pass type II membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus, and ventral striatum. NAALADase L is a chloride-activated, membrane-bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.

参考文献

1. Stauch BL. 1989, Neurosci Lett. 100 (1-3): 295-300. 2. Shneider BL. et al., 1997, J. Biol. Chem. 272: 31006-15. 3. Pangalos MN. et al., 1999, J. Biol. Chem. 274: 8470-83. 4. Thomas AG. et al., 1999, Brain Res. 843 (1-2): 48-52.

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NAALADL1 Protein, Human, Recombinant (His)

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