NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 35.8 kDa and the accession number is Q02297-1.
説明 | NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 35.8 kDa and the accession number is Q02297-1. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | N-hFc |
Accession Number | Q02297-1 |
別名 | HRG1, NRG1-IT2, HRGA, NRG1 α, HGL, neuregulin 1, SMDF, MSTP131, NDF, HRG, ARIA, MST131, GGF, GGF2 |
Construction | The Human NRG1 isoform alpha (Q02297-1) EGF-like domain (Ser 177-Lys 241) was fused with the Fc region of Human IgG1 at the N-terminus. |
Protein Purity | > 97 % as determined by SDS-PAGE |
分子量 | 35.8 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. |
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Please read the User Guide of Recombinant Proteins for more specific information.
NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) HRG1 NRG1-IT2 HRGA HRG-1 GGF-2 MSTP-131 HRG 1 NRG1 α MSTP 131 HGL neuregulin 1 SMDF MSTP131 GGF 2 NDF HRG MST-131 ARIA MST131 GGF MST 131 GGF2 recombinant recombinant-proteins proteins protein