Oncostatin M/OSM Protein, Canine, Recombinant (His)

Oncostatin M/OSM Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 21.65 kDa and the accession number is A0A8I3Q5M1.

Oncostatin M/OSM Protein, Canine, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 112,000
500 μg	約5 days	￥ 447,500
1 mg	約5 days	￥ 746,000

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説明	Oncostatin M/OSM Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 21.65 kDa and the accession number is A0A8I3Q5M1.

Species	Canine
Expression Host	HEK293 Cells
Tag	C-His
Accession Number	A0A8I3Q5M1
別名	Oncostatin M, OSM, MGC20461
Construction	Ser27-Arg207
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	21.65 kDa (predicted). Due to glycosylation, the protein migrates to 27-35 kDa based on Tris-Bis PAGE result.

Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Stability & Storage	It is recommended to store the product under sterile conditions at -70℃ or lower. Samples are stable for up to 12 months at -80℃. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.

参考文献

1. Junk D J, et al. Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling[J]. Oncogene, 2017.

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Oncostatin M/OSM Protein, Canine, Recombinant (His)

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