OSMR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.6 kDa and the accession number is Q99650-1.
パッケージサイズ | 在庫状況 | 単価(税別) |
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100 μg | 在庫あり | ¥ 75,500 |
200 μg | 約5 days | ¥ 134,000 |
500 μg | 約5 days | ¥ 282,500 |
生物学的情報 |
1.Loaded Anti-Human OSMR antibody, human IgG1 on ProA Biosensor, can bind Recombinant Human OSMR Protein, His Tag with an affinity constant of 0.40 nM as determined in a BLI assay (Routinely tested).
2. Immobilized Anti-OSMRβ Antibody at 2 μg/mL (100 μL/well) can bind Recombinant Human OSMR / IL31RB Protein (His Tag), the EC50 is 4-12 ng/mL.
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説明 | OSMR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.6 kDa and the accession number is Q99650-1. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | His |
Accession Number | Q99650-1 |
別名 | OSMRB, PLCA1, oncostatin M receptor, IL-31RB |
Construction | The Human OSMR (NP_003990.1) extracellular domain (Met 1-Met 740) was expressed, fused with a polyhistidine tag at the C-terminus. |
Protein Purity |
≥ 96 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
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分子量 | 82.6 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis of familial cutaneous lichen amyloidosis. PLCA1 is hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. |
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Please read the User Guide of Recombinant Proteins for more specific information.
OSMR Protein, Human, Recombinant (His) OSMRB PLCA 1 PLCA1 PLCA-1 oncostatin M receptor IL-31RB recombinant recombinant-proteins proteins protein