OX40L/TNFSF4 Protein, Mouse, Recombinant (mFc)

OX40L/TNFSF4 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.7 kDa and the accession number is B6DXE3.

OX40L/TNFSF4 Protein, Mouse, Recombinant (mFc)

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 82,000
500 μg	約5 days	￥ 385,500

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説明	OX40L/TNFSF4 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.7 kDa and the accession number is B6DXE3.

Species	Mouse
Expression Host	HEK293 Cells
Tag	N-mFc
Accession Number	B6DXE3
別名	Ath1, OX-40L, TXGP1, CD134L, gp34, tumor necrosis factor (ligand) superfamily, member 4, Ath-1, Ox40l, Txgp1l
Construction	The Mouse Tnfsf4 ( NP_033478.1) (Gln49-Leu198) was expressed with the Fc region of Mouse IgG1 at the N-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE.
分子量	42.7 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4. 2. Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4. 3. Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.

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OX40L/TNFSF4 Protein, Mouse, Recombinant (mFc)

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