PCSK9 Protein, Mouse, Recombinant (His)

PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.

PCSK9 Protein, Mouse, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
20 μg	約5 days	￥ 38,000
100 μg	約5 days	￥ 138,000
1 mg	約5 days	￥ 897,500

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説明	PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.

Species	Mouse
Expression Host	HEK293 Cells
Tag	C-His
Accession Number	Q80W65
別名	proprotein convertase subtilisin/kexin type 9, AI747682, Narc1, FH3, PC9, AI415265, HCHOLA3
Construction	The full length of Mouse PCSK9 (NP_705793.1) precursor (Met 1-Gln 694) was expressed, with a C-terminal polyhistidine tag.
Protein Purity	> 95 % as determined by SDS-PAGE
分子量	72.6 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 15 mM Tris, 90 mM NaCl, 50% Glycerol, pH 7.5.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

参考文献

1. Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933. 2. Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498 3. Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73. 4. Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875. 5. Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.

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PCSK9 Protein, Mouse, Recombinant (His)

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