PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
10 μg | 約5 days | ¥ 25,500 |
50 μg | 約5 days | ¥ 71,500 |
500 μg | 約5 days | ¥ 360,500 |
1 mg | 約5 days | ¥ 512,000 |
説明 | PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7. |
Species | Cynomolgus |
Expression Host | HEK293 Cells |
Tag | C-6xHis |
Accession Number | G7PSE7 |
別名 | B7-H, B7-H1, PDL1, PDCD1L1, PDL1PDCD1 ligand 1, CD274 antigenMGC142294, PDCD1LG1, Programmed death ligand 1, PD-L1B7 homolog 1, CD274 molecule, CD274, PD-L1, programmed cell death 1 ligand 1, B7H1, B7H1PDCD1L1 |
Amino Acid | Phe19-Thr239 |
Construction | Phe19-Thr239 |
Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 32-40 KDa, reducing conditions |
Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers. |
bottom
Please read the User Guide of Recombinant Proteins for more specific information.
PD-L1 Protein, Cynomolgus, Recombinant (His) B7-H B7-H1 PDL1 CD274 antigenMGC-142294 PDCD1L1 PDL1PDCD1 ligand 1 CD274 antigenMGC142294 PDCD1LG1 CD-274 PDL 1 Programmed death ligand 1 CD 274 PD-L1B7 homolog 1 CD274 antigenMGC 142294 PDL-1 CD274 molecule CD274 PD-L1 programmed cell death 1 ligand 1 B7H1 B7H1PDCD1L1 recombinant recombinant-proteins proteins protein