Peroxiredoxin 1 Protein, Mouse, Recombinant (His)

Peroxiredoxin 1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.5 kDa and the accession number is P35700.

Peroxiredoxin 1 Protein, Mouse, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 114,500

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説明	Peroxiredoxin 1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.5 kDa and the accession number is P35700.

Species	Mouse
Expression Host	E. coli
Tag	His
Accession Number	P35700
別名	PAG, OSF-3, OSF3, Paga, PRDX1, Tdpx2, PrxI, TDX2, TPxA, prx1, peroxiredoxin 1, NkefA, MSP23, PrdxI
Construction	A DNA sequence encoding the mouse PRDX1 (P35700) (Met 1-Lys 199) was expressed, with a C-terminal polyhistidine tag.
Protein Purity	> 85 % as determined by SDS-PAGE
分子量	23.5 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from sterile PBS, 10% glycerol, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.

参考文献

1. Neumann, CA. et al., 2003, Nature 424 (6948): 561-5 2. Gisin, J. et al., 2005, J Clin Pathol. 58 (11): 1229-31. 3. Hoshino, I. et al., 2007, Oncol Rep. 18 (4): 867-71. 4. Cao, J. et al., 2009, EMBO J. 28 (10): 1505-17.

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Peroxiredoxin 1 Protein, Mouse, Recombinant (His)

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