Protein S/PROS1 Protein, Human, Recombinant (His)

Protein S/PROS1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.1 kDa and the accession number is P07225.

Protein S/PROS1 Protein, Human, Recombinant (His)

パッケージサイズ	在庫状況	単価(税別)
100 μg	在庫あり	￥ 138,000

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生物学的情報	Testing in progress
説明	Protein S/PROS1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.1 kDa and the accession number is P07225.

Species	Human
Expression Host	HEK293 Cells
Tag	C-His
Accession Number	P07225
別名	PS21, PSA, PS23, PS22, THPH6, PS25, Protein S, THPH5, protein S (α), protein S (alpha), PROS, PS24
Construction	The Human PROS1 (P07225) (Met1-Ser676) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE
分子量	74.1 kDa (predicted)

Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	PROS1, also known as protein S, is a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. PROS1 has two isoforms: a free, functionally active form and an inactive form complexed with C4b-binding protein. Besides its anticoagulant function, PROS1 also acts as an agonist for the tyrosine kinase receptors Tyro3, Axl, and Mer. The endothelium expresses Tyro3, Axl, and Mer and produces protein S. The interaction of protein S with endothelial cells and particularly its effects on angiogenesis have not yet been analyzed.

参考文献

1. Beauchamp NJ. et al., 2004, Br J Haematol. 125 (5): 647-54. 2. García de Frutos P. et al., 2007, Thromb Haemost. 98 (3): 543-56. 3. Rezende SM. et al., 2004, Blood. 103 (4): 1192-201.

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Protein S/PROS1 Protein, Human, Recombinant (His)

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