RANK/TNFRSF11A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9Y6Q6-3.
説明 | RANK/TNFRSF11A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9Y6Q6-3. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-mFc |
Accession Number | Q9Y6Q6-3 |
別名 | OFE, RANK, OPTB7, FEO, tumor necrosis factor receptor superfamily member 11a, LOH18CR1, OSTS, PDB2, TRANCER, CD265, ODFR, TNFRSF11A |
Construction | The Human TNFRSF11A (NP_001257879.1) (Met1-Pro212) was expressed with the Fc region of Mouse IgG2a at the C-terminus. |
Protein Purity | > 95 % as determined by SDS-PAGE. |
分子量 | 46.5 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone. |
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Please read the User Guide of Recombinant Proteins for more specific information.
RANK/TNFRSF11A Protein, Human, Recombinant (mFc) OFE PDB-2 RANK OPTB-7 OPTB 7 OPTB7 FEO tumor necrosis factor receptor superfamily member 11a LOH18CR1 OSTS PDB2 CD-265 TRANCER CD265 CD 265 PDB 2 ODFR TNFRSF11A recombinant recombinant-proteins proteins protein