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RheB Protein, Human, Recombinant (GST)

カタログ番号 TMPJ-01126
別名: RHEB, Ras Homolog Enriched in Brain, GTP-Binding Protein Rheb, RHEB2

GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling, and it activates the protein kinase activity of mTORC1. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, farnesylation of the protein is required for this activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
RheB Protein, Human, Recombinant (GST)
パッケージサイズ 在庫状況 単価(税別)
10 μg 約5 days ¥ 42,500
50 μg 約5 days ¥ 125,000
500 μg 約5 days ¥ 475,000
1 mg 約5 days ¥ 682,000
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生物学的特性に関する説明
Technical Params
Product Properties
説明 GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling, and it activates the protein kinase activity of mTORC1. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, farnesylation of the protein is required for this activity.
Species Human
Expression Host E. coli
Tag N-GST
Accession Number Q15382
別名 RHEB, Ras Homolog Enriched in Brain, GTP-Binding Protein Rheb, RHEB2
Amino Acid Met1-Met184
Construction Met1-Met184
Protein Purity Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
分子量 45 KDa (reducing condition)
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 8% Trehalose, 4% Mannitol, 50 mM NaCl, 10 mM GSH, 0.05% Tween 80, pH6.5.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling, and it activates the protein kinase activity of mTORC1. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, farnesylation of the protein is required for this activity.

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技術サポート

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

RheB Protein, Human, Recombinant (GST) RHEB RHEB-2 Ras Homolog Enriched in Brain RHEB 2 GTP-Binding Protein Rheb RHEB2 recombinant recombinant-proteins proteins protein