RP105/CD180 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69 kDa and the accession number is Q99467.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
50 μg | 在庫あり | ¥ 73,500 |
100 μg | 約5 days | ¥ 130,500 |
200 μg | 約5 days | ¥ 229,500 |
500 μg | 約5 days | ¥ 486,500 |
生物学的情報 | Testing in progress |
説明 | RP105/CD180 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69 kDa and the accession number is Q99467. |
Species | Human |
Expression Host | HEK293 Cells |
Tag | C-His |
Accession Number | Q99467 |
別名 | CD180 molecule, Ly78, RP105, LY64 |
Construction | The Human CD180 (NP_005573.2) extracellular domain (Met 1-Gly 626) was fused with a polyhistidine tag at the C-terminus. |
Protein Purity |
≥ 90 % as determined by SDS-PAGE
|
分子量 | 69 kDa (predicted) |
Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Stability & Storage |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping |
In general, Lyophilized powders are shipping with blue ice. |
Research Background | The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interacts with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS. |
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Please read the User Guide of Recombinant Proteins for more specific information.
RP105/CD180 Protein, Human, Recombinant (His) CD180 molecule LY 64 LY-64 Ly78 RP-105 RP105 RP 105 LY64 recombinant recombinant-proteins proteins protein