S100A11 Protein, Human, Recombinant

S100A11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24 and 12 kDa and the accession number is P31949.

S100A11 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
50 μg	約5 days	￥ 138,000

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説明	S100A11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 24 and 12 kDa and the accession number is P31949.

Species	Human
Expression Host	E. coli
Tag	Tag Free
Accession Number	P31949
別名	S100C, HEL-S-43, S100 calcium binding protein A11, MLN70
Construction	native Human S100A11 (NP_005611.1) (Met 1-Thr 105)
Protein Purity	> 97 % as determined by SDS-PAGE
分子量	24 & 12 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferation of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma.

参考文献

1. Miyasaki KT. et al., 1993, J Dent Res. 72: 517-23. 2. Ohuchida K. et al., 2006, Clin Cancer Res 12 (18): 5417-22. 3. Kouno T. et al., 2008, J Pept Sci. 14 (10): 1129-38. 4. He H. et al., 2009, Cell Biochem Biophys 55 (3): 117-26. 5. Liu XG. et al., 2010, Oncol Rep. 23 (5): 1301-8.

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S100A11 Protein, Human, Recombinant

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