S100A13 Protein, Human, Recombinant

S100A13 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.6 kDa and the accession number is Q99584.

S100A13 Protein, Human, Recombinant

パッケージサイズ	在庫状況	単価(税別)
100 μg	約5 days	￥ 138,000

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説明	S100A13 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.6 kDa and the accession number is Q99584.

Species	Human
Expression Host	E. coli
Tag	Tag Free
Accession Number	Q99584
別名	protein S100-A13, OTTHUMP00000034802, S100 calcium-binding protein A13, S100 calcium binding protein A13
Construction	native Human S100A13 (NP_001019381.1) (Met 1-Lys 98)
Protein Purity	> 98 % as determined by SDS-PAGE
分子量	11.6 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 100 mM NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A13, also known as S100 calciumbinding protein A13, is a member of the S-100 family. It contains two EF-hand domains. S100A13 binds two calcium ions per subunit and one copper ion. Binding of one copper ion does not interfere with calcium-binding. S100A13 is required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine. S100A13 plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway.

参考文献

1. Mandinova A. et al., 2003, J Cell Sci. 116: 2687-96. 2. Arnesano F. et al., 2005, Angew Chem Int Ed. 44: 6341-4. 3. Viemann D. et al., 2005, Blood. 105: 2955-62. 4. Nakatani Y. et al., 2005, Mediators Inflamm. 2005: 280-92. 5. Bjoerk P. et al., 2009, PLoS Biol. 7: E97-E97.

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S100A13 Protein, Human, Recombinant

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